Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5EJK

Crystal structure of the Rous sarcoma virus intasome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
C	0003676	molecular_function	nucleic acid binding
C	0008270	molecular_function	zinc ion binding
C	0015074	biological_process	DNA integration
D	0003676	molecular_function	nucleic acid binding
D	0008270	molecular_function	zinc ion binding
D	0015074	biological_process	DNA integration
E	0003676	molecular_function	nucleic acid binding
E	0008270	molecular_function	zinc ion binding
E	0015074	biological_process	DNA integration
F	0003676	molecular_function	nucleic acid binding
F	0008270	molecular_function	zinc ion binding
F	0015074	biological_process	DNA integration
G	0003676	molecular_function	nucleic acid binding
G	0008270	molecular_function	zinc ion binding
G	0015074	biological_process	DNA integration
H	0003676	molecular_function	nucleic acid binding
H	0008270	molecular_function	zinc ion binding
H	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS9
A	HIS13
A	CYS37
A	CYS40

site_id	AC2
Number of Residues	3
Details	binding site for residue W A 302

Chain	Residue
A	W303
A	W304
B	W320

site_id	AC3
Number of Residues	3
Details	binding site for residue W A 303

Chain	Residue
B	W321
A	W302
B	W314

site_id	AC4
Number of Residues	3
Details	binding site for residue W A 304

Chain	Residue
A	W302
B	W314
B	W318

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS9
B	HIS13
B	CYS37
B	CYS40

site_id	AC6
Number of Residues	4
Details	binding site for residue W B 302

Chain	Residue
B	W307
B	W308
B	W310
B	W312

site_id	AC7
Number of Residues	3
Details	binding site for residue W B 303

Chain	Residue
B	W307
B	W308
B	W313

site_id	AC8
Number of Residues	4
Details	binding site for residue W B 304

Chain	Residue
B	W306
B	W311
B	W312
B	W313

site_id	AC9
Number of Residues	4
Details	binding site for residue W B 305

Chain	Residue
B	W306
B	W309
B	W310
B	W311

site_id	AD1
Number of Residues	4
Details	binding site for residue W B 306

Chain	Residue
B	W304
B	W305
B	W309
B	W313

site_id	AD2
Number of Residues	3
Details	binding site for residue W B 307

Chain	Residue
B	W302
B	W303
B	W313

site_id	AD3
Number of Residues	4
Details	binding site for residue W B 308

Chain	Residue
B	W302
B	W303
B	W309
B	W310

site_id	AD4
Number of Residues	3
Details	binding site for residue W B 309

Chain	Residue
B	W305
B	W306
B	W308

site_id	AD5
Number of Residues	3
Details	binding site for residue W B 310

Chain	Residue
B	W302
B	W305
B	W308

site_id	AD6
Number of Residues	3
Details	binding site for residue W B 311

Chain	Residue
B	W304
B	W305
B	W312

site_id	AD7
Number of Residues	3
Details	binding site for residue W B 312

Chain	Residue
B	W302
B	W304
B	W311

site_id	AD8
Number of Residues	4
Details	binding site for residue W B 313

Chain	Residue
B	W303
B	W304
B	W306
B	W307

site_id	AD9
Number of Residues	5
Details	binding site for residue W B 314

Chain	Residue
A	ARG74
A	W303
A	W304
B	ARG74
B	W321

site_id	AE1
Number of Residues	4
Details	binding site for residue W B 315

Chain	Residue
B	W317
B	W319
B	W320
B	W321

site_id	AE2
Number of Residues	3
Details	binding site for residue W B 316

Chain	Residue
B	W317
B	W318
B	W319

site_id	AE3
Number of Residues	4
Details	binding site for residue W B 317

Chain	Residue
B	W315
B	W316
B	W318
B	W321

site_id	AE4
Number of Residues	4
Details	binding site for residue W B 318

Chain	Residue
A	W304
B	ARG74
B	W316
B	W317

site_id	AE5
Number of Residues	3
Details	binding site for residue W B 319

Chain	Residue
B	W315
B	W316
B	W320

site_id	AE6
Number of Residues	3
Details	binding site for residue W B 320

Chain	Residue
A	W302
B	W315
B	W319

site_id	AE7
Number of Residues	5
Details	binding site for residue W B 321

Chain	Residue
A	W303
B	PRO73
B	W314
B	W315
B	W317

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS9
C	HIS13
C	CYS37
C	CYS40

site_id	AE9
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS9
D	HIS13
D	CYS37
D	CYS40

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN E 301

Chain	Residue
E	HIS13
E	CYS37
E	CYS40
E	HIS9

site_id	AF2
Number of Residues	4
Details	binding site for residue ZN F 301

Chain	Residue
F	HIS9
F	HIS13
F	CYS37
F	CYS40

site_id	AF3
Number of Residues	4
Details	binding site for residue W F 302

Chain	Residue
F	W307
F	W309
F	W311
G	W301

site_id	AF4
Number of Residues	3
Details	binding site for residue W F 303

Chain	Residue
F	W307
F	W312
G	W301

site_id	AF5
Number of Residues	4
Details	binding site for residue W F 304

Chain	Residue
F	W306
F	W310
F	W311
F	W312

site_id	AF6
Number of Residues	4
Details	binding site for residue W F 305

Chain	Residue
F	W306
F	W308
F	W309
F	W310

site_id	AF7
Number of Residues	5
Details	binding site for residue W F 306

Chain	Residue
F	ARG70
F	W304
F	W305
F	W308
F	W312

site_id	AF8
Number of Residues	4
Details	binding site for residue W F 307

Chain	Residue
F	W302
F	W303
F	W308
F	W309

site_id	AF9
Number of Residues	3
Details	binding site for residue W F 308

Chain	Residue
F	W305
F	W306
F	W307

site_id	AG1
Number of Residues	3
Details	binding site for residue W F 309

Chain	Residue
F	W302
F	W305
F	W307

site_id	AG2
Number of Residues	3
Details	binding site for residue W F 310

Chain	Residue
F	W304
F	W305
F	W311

site_id	AG3
Number of Residues	3
Details	binding site for residue W F 311

Chain	Residue
F	W302
F	W304
F	W310

site_id	AG4
Number of Residues	4
Details	binding site for residue W F 312

Chain	Residue
F	W303
F	W304
F	W306
G	W301

site_id	AG5
Number of Residues	3
Details	binding site for residue W G 301

Chain	Residue
F	W302
F	W303
F	W312

site_id	AG6
Number of Residues	4
Details	binding site for residue ZN G 302

Chain	Residue
G	HIS9
G	HIS13
G	CYS37
G	CYS40

site_id	AG7
Number of Residues	4
Details	binding site for residue ZN H 301

Chain	Residue
H	HIS9
H	HIS13
H	CYS37
H	CYS40

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	384
Details	DNA_BIND: Integrase-type => ECO:0000255\|PROSITE-ProRule:PRU00506

Chain	Residue	Details
A	PRO222-THR270
B	PRO222-THR270
C	PRO222-THR270
D	PRO222-THR270
E	PRO222-THR270
F	PRO222-THR270
G	PRO222-THR270
H	PRO222-THR270

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	HIS9
E	HIS13
F	HIS9
F	HIS13
G	HIS9
G	HIS13
H	HIS9
H	HIS13
A	HIS13
B	HIS9
B	HIS13
C	HIS9
C	HIS13
D	HIS9
D	HIS13
E	HIS9

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00450, ECO:0000269\|PubMed:26887497

Chain	Residue	Details
A	CYS37
E	CYS40
F	CYS37
F	CYS40
G	CYS37
G	CYS40
H	CYS37
H	CYS40
A	CYS40
B	CYS37
B	CYS40
C	CYS37
C	CYS40
D	CYS37
D	CYS40
E	CYS37

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00405, ECO:0000269\|PubMed:10669607

Chain	Residue	Details
A	ASP64
E	ASP121
F	ASP64
F	ASP121
G	ASP64
G	ASP121
H	ASP64
H	ASP121
A	ASP121
B	ASP64
B	ASP121
C	ASP64
C	ASP121
D	ASP64
D	ASP121
E	ASP64

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:10669607

Chain	Residue	Details
A	GLU157
B	GLU157
C	GLU157
D	GLU157
E	GLU157
F	GLU157
G	GLU157
H	GLU157

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)