5EI3
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic translation initiation factor 4E | polymer | 217 | 25130.2 | 1 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (Human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
| 2 | B (B) | Eukaryotic translation initiation factor 4 gamma | polymer | 14 | 1851.2 | 1 | UniProt (by SIFTS) (Q04637) | synthetic construct | |
| 3 | C (A) | ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide | non-polymer | 505.4 | 1 | Chemie (5O8) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26981.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 601.5 | |
| All* | Total formula weight | 27582.9 |
