5EI3
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0000339 | molecular_function | RNA cap binding |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0001662 | biological_process | behavioral fear response |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006412 | biological_process | translation |
| A | 0006413 | biological_process | translational initiation |
| A | 0006417 | biological_process | regulation of translation |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0010507 | biological_process | negative regulation of autophagy |
| A | 0016281 | cellular_component | eukaryotic translation initiation factor 4F complex |
| A | 0016442 | cellular_component | RISC complex |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0019827 | biological_process | stem cell population maintenance |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030182 | biological_process | neuron differentiation |
| A | 0031370 | molecular_function | eukaryotic initiation factor 4G binding |
| A | 0033391 | cellular_component | chromatoid body |
| A | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| A | 0045665 | biological_process | negative regulation of neuron differentiation |
| A | 0045931 | biological_process | positive regulation of mitotic cell cycle |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051028 | biological_process | mRNA transport |
| A | 0051168 | biological_process | nuclear export |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071549 | biological_process | cellular response to dexamethasone stimulus |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098808 | molecular_function | mRNA cap binding |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099578 | biological_process | regulation of translation at postsynapse, modulating synaptic transmission |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 5O8 A 301 |
| Chain | Residue |
| A | TRP56 |
| A | SO4302 |
| A | HOH421 |
| A | HOH465 |
| A | HOH525 |
| A | HOH545 |
| A | HOH583 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG112 |
| A | TRP166 |
| A | HIS200 |
| A | THR203 |
| A | ALA204 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG157 |
| A | 5O8301 |
| A | HOH420 |
| A | HOH425 |
| A | HOH436 |
| A | HOH451 |
| A | HOH525 |
| A | HOH592 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
