5DSY
Crystal structure of constitutively active PARP-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Poly [ADP-ribose] polymerase 2 | polymer | 280 | 31675.9 | 4 | UniProt (Q9UGN5) Pfam (PF00644) | Homo sapiens (Human) | hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2 |
| 2 | E, F, G, H (A, B, C, D) | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide | non-polymer | 537.5 | 4 | Chemie (UHB) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 335 - 570 (UniProt: Q9UGN5)
| PDB | External Database | Details |
|---|---|---|
| Met 197 | - | initiating methionine |
| Gly 198 | - | expression tag |
| Ser 199 | - | expression tag |
| Ser 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| His 205 | - | expression tag |
| His 206 | - | expression tag |
| Ser 207 | - | expression tag |
| Ser 208 | - | expression tag |
| Gly 209 | - | expression tag |
| Leu 210 | - | expression tag |
| Val 211 | - | expression tag |
| Pro 212 | - | expression tag |
| Arg 213 | - | expression tag |
| Gly 214 | - | expression tag |
| Ser 215 | - | expression tag |
| His 216 | - | expression tag |
| Pro 217 | - | expression tag |
| Glu 218 | - | expression tag |
| Ser 219 | - | expression tag |
| Gln 220 | - | expression tag |
| Leu 221 | - | expression tag |
| Asp 222 | - | expression tag |
| Leu 223 | - | expression tag |
| Arg 224 | - | expression tag |
| Val 225 | - | expression tag |
| Gln 226 | - | expression tag |
| Glu 227 | - | expression tag |
| Leu 228 | - | expression tag |
| Ile 229 | - | expression tag |
| Lys 230 | - | expression tag |
| Leu 231 | - | expression tag |
| Ile 232 | - | expression tag |
| Cys 233 | - | expression tag |
| Asn 234 | - | expression tag |
| Val 329 | - | expression tag |
| Gln 330 | - | expression tag |
| Ala 331 | - | expression tag |
| Met 332 | - | expression tag |
| Glu 333 | - | expression tag |
| Glu 334 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126703.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2150.1 | |
| All* | Total formula weight | 128853.8 |
