5DSY

Crystal structure of constitutively active PARP-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue UHB A 1001

Chain	Residue
A	TRP414
A	ALA433
A	TYR449
A	SER457
A	TYR460
A	GLU545
A	HOH1112
A	HIS415
A	GLY416
A	SER417
A	ASN421
A	GLY424
A	ILE425
A	GLY429
A	ARG431

---

site_id	AC2
Number of Residues	15
Details	binding site for residue UHB B 1001

Chain	Residue
B	TRP414
B	HIS415
B	GLY416
B	SER417
B	GLY424
B	ILE425
B	GLY429
B	LEU430
B	ARG431
B	ALA433
B	PRO434
B	TYR449
B	SER457
B	TYR460
B	GLU545

---

site_id	AC3
Number of Residues	16
Details	binding site for residue UHB C 1001

Chain	Residue
A	LEU466
C	HIS415
C	GLY416
C	SER417
C	ASN421
C	GLY424
C	ILE425
C	GLY429
C	ARG431
C	ALA433
C	TYR449
C	SER457
C	TYR460
C	GLU545
C	HOH1106
C	HOH1114

---

site_id	AC4
Number of Residues	14
Details	binding site for residue UHB D 1001

Chain	Residue
B	LEU466
D	HIS415
D	GLY416
D	SER417
D	ASN421
D	GLY424
D	ILE425
D	GLY429
D	ARG431
D	PRO434
D	TYR442
D	TYR449
D	SER457
D	TYR460

---

Functional Information from PROSITE/UniProt

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANPKA

Chain	Residue	Details
A	LEU485-ALA492

---

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgsrmSnwVgILSHG

Chain	Residue	Details
A	HIS415-GLY429

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"26704974","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30104678","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TX3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	227
Details	Domain: {"description":"PARP catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00397","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---