5DQ8

Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcriptional enhancer factor TEF-4	polymer	240	27489.1	2	UniProt (Q15562) Pfam (PF17725)	Homo sapiens (Human)	TEA domain family member 2,TEAD-2
2	C, D, E (A, B)	2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID	non-polymer		281.2	3	Chemie (FLF)
3	F, G (A, B)	water	water		18.0	85	Chemie (HOH)

Sequence modifications

A, B: 217 - 447 (UniProt: Q15562)

PDB	External Database	Details
Met 216	-	initiating methionine
Val 448	-	expression tag
Glu 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54978.2
Non-Polymers*	Number of molecules	3
	Total formula weight	843.7
All*	Total formula weight	55821.9

*Water molecules are not included.