5DKD
Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Transcription activator BRG1 | polymer | 121 | 14230.4 | 2 | UniProt (P51532) Pfam (PF00439) In PDB | Homo sapiens (Human) | ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | A, B | (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one | non-polymer | 321.4 | 2 | Chemie (5BW) | |||
| 5 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B: 1451 - 1569 (UniProt: P51532)
| PDB | External Database | Details |
|---|---|---|
| Ser 1449 | - | expression tag |
| Met 1450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28460.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1146.0 | |
| All* | Total formula weight | 29606.9 |
