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5D7O

Crystal structure of Sirt2-ADPR at an improved resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
NAD-dependent protein deacetylase sirtuin-2polymer31035018.42UniProt (Q8IXJ6)
Pfam (PF02146)
Homo sapiens (Human)Regulatory protein SIR2 homolog 2,SIR2-like protein 2
2C, E
(A, B)
ZINC IONnon-polymer65.42Chemie (ZN)
3D, F
(A, B)
[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATEnon-polymer559.32Chemie (AR6)
4G
(B)
TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
5H, I
(A, B)
waterwater18.0213Chemie (HOH)
Sequence modifications
A, B: 50 - 356 (UniProt: Q8IXJ6)
PDBExternal DatabaseDetails
Gly 47-expression tag
His 48-expression tag
Met 49-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70036.8
Non-Polymers*Number of molecules5
Total formula weight1399.6
All*Total formula weight71436.4
*Water molecules are not included.

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PDB entries from 2025-07-23

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