5D7O
Crystal structure of Sirt2-ADPR at an improved resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue AR6 A 402 |
| Chain | Residue |
| A | PHE96 |
| A | ARG97 |
| A | TYR104 |
| A | GLN167 |
| A | HIS187 |
| A | PHE235 |
| A | GLY261 |
| A | THR262 |
| A | SER263 |
| A | VAL266 |
| A | ASN286 |
| A | LYS287 |
| A | GLU288 |
| A | GLY322 |
| A | GLU323 |
| A | CYS324 |
| A | HOH502 |
| A | HOH505 |
| A | HOH516 |
| A | HOH539 |
| A | HOH563 |
| A | GLY84 |
| A | ALA85 |
| A | GLY86 |
| A | THR89 |
| A | ASP95 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | binding site for residue AR6 B 402 |
| Chain | Residue |
| B | GLY84 |
| B | ALA85 |
| B | GLY86 |
| B | THR89 |
| B | ASP95 |
| B | PHE96 |
| B | ARG97 |
| B | TYR104 |
| B | GLN167 |
| B | HIS187 |
| B | PHE235 |
| B | GLY261 |
| B | THR262 |
| B | SER263 |
| B | VAL266 |
| B | ASN286 |
| B | LYS287 |
| B | GLU288 |
| B | GLY322 |
| B | GLU323 |
| B | CYS324 |
| B | HOH504 |
| B | HOH507 |
| B | HOH512 |
| B | HOH513 |
| B | HOH535 |
| B | HOH569 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PGE B 403 |
| Chain | Residue |
| B | LYS289 |
| B | ALA319 |
| B | TRP320 |
| B | LEU321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 562 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
