5D75

Crystal structure of Human FKBD25 in complex with FK506

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peptidyl-prolyl cis-trans isomerase FKBP3	polymer	124	14031.1	1	UniProt (Q00688) Pfam (PF00254)	Homo sapiens (Human)	PPIase FKBP3,25 kDa FK506-binding protein,FKBP-25,FK506-binding protein 3,FKBP-3,Immunophilin FKBP25,Rapamycin-selective 25 kDa immunophilin,Rotamase
2	B (A)	8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN	non-polymer		804.0	1	Chemie (FK5) PubChem (403209) PubChem (439492) PubChem (5353987) PubChem (5472317) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (9940643) PubChem (13819073) PubChem (23377000) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (44294761) PubChem (44314852) PubChem (44575549) PubChem (46783859) PubChem (46781577) PubChem (49874294) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (54611630) PubChem (123552884) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (57206900) PubChem (130330191) PubChem (131676819) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (149048732) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (166023667) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (59746606) PubChem (173882479) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (66509027) PubChem (66672804) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (89068341) PubChem (124511204) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (125182986) PubChem (126687738) PubChem (129606865) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550)
3	C, D (A)	O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)	non-polymer		597.8	2	Chemie (JEF) PubChem (45480539) PubChem (52949055) PubChem (138753275)
4	E (A)	water	water		18.0	106	Chemie (HOH)

Sequence modifications

A: 109 - 224 (UniProt: Q00688)

PDB	External Database	Details
Leu 225	-	expression tag
Glu 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14031.1
Non-Polymers*	Number of molecules	3
	Total formula weight	1999.7
All*	Total formula weight	16030.8

*Water molecules are not included.