5D75

Crystal structure of Human FKBD25 in complex with FK506

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue FK5 A 301

Chain	Residue
A	TYR135
A	GLN203
A	ALA206
A	ILE208
A	PHE216
A	JEF303
A	HOH405
A	HOH420
A	HOH439
A	PHE145
A	ASP146
A	LEU162
A	LYS170
A	VAL171
A	ILE172
A	TRP175
A	TYR198

---

site_id	AC2
Number of Residues	2
Details	binding site for residue JEF A 302

Chain	Residue
A	GLY169
A	LYS170

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site_id	AC3
Number of Residues	7
Details	binding site for residue JEF A 303

Chain	Residue
A	PRO194
A	GLU195
A	GLY199
A	LYS200
A	LYS201
A	ASN211
A	FK5301

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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