5CL1

Complex structure of Norrin with human Frizzled 4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltose-binding periplasmic protein,Norrin	polymer	483	53664.0	2	UniProt (P0AEY0) UniProt (Q00604) Pfam (PF01547) Pfam (PF00007)	Escherichia coli O157:H7	MBP,MMBP,Maltodextrin-binding protein,Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein
2	C, D (C, D)	Frizzled-4	polymer	131	15098.3	2	UniProt (Q9ULV1) Pfam (PF01392)	Homo sapiens (Human)	hFz4,FzE4
3	E, F, G, H (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 0 - 366 (UniProt: P0AEY0)

PDB	External Database	Details
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Asn 367	-	linker
Ala 368	-	linker
Ala 369	-	linker
Ala 370	-	linker

A, B: 1031 - 1133 (UniProt: Q00604)
C, D: 38 - 160 (UniProt: Q9ULV1)

PDB	External Database	Details
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137524.8
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	138409.6

*Water molecules are not included.