5CL1

Complex structure of Norrin with human Frizzled 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005109	molecular_function	frizzled binding
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007033	biological_process	vacuole organization
A	0007399	biological_process	nervous system development
A	0007601	biological_process	visual perception
A	0008643	biological_process	carbohydrate transport
A	0009986	cellular_component	cell surface
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0016055	biological_process	Wnt signaling pathway
A	0035426	biological_process	extracellular matrix-cell signaling
A	0042803	molecular_function	protein homodimerization activity
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046697	biological_process	decidualization
A	0055085	biological_process	transmembrane transport
A	0110135	biological_process	Norrin signaling pathway
B	0005109	molecular_function	frizzled binding
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007033	biological_process	vacuole organization
B	0007399	biological_process	nervous system development
B	0007601	biological_process	visual perception
B	0008643	biological_process	carbohydrate transport
B	0009986	cellular_component	cell surface
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0016055	biological_process	Wnt signaling pathway
B	0035426	biological_process	extracellular matrix-cell signaling
B	0042803	molecular_function	protein homodimerization activity
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046697	biological_process	decidualization
B	0055085	biological_process	transmembrane transport
B	0110135	biological_process	Norrin signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO107-ASN124

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site_id	PS01185
Number of Residues	37
Details	CTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C

Chain	Residue	Details
A	CYS1095-CYS1131

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	186
Details	Domain: {"description":"CTCK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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