5CJ7
Human DNA polymerase lambda L431A mutant- MgdTTP binary and complex with 6 paired DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DNA polymerase lambda | polymer | 334 | 37306.5 | 2 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) In PDB | Homo sapiens (Human) | Pol Lambda,DNA polymerase beta-2,Pol beta2,DNA polymerase kappa |
| 2 | P | DNA (5'-D(*CP*AP*GP*TP*AP*C)-3') | polymer | 6 | 1793.2 | 1 | synthetic construct | ||
| 3 | T | DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3') | polymer | 6 | 1824.2 | 1 | synthetic construct | ||
| 4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | B | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) | |||
| 6 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 242 - 575 (UniProt: Q9UGP5)
| PDB | External Database | Details |
|---|---|---|
| Ala 431 | Leu 431 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 78230.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 506.5 | |
| All* | Total formula weight | 78736.9 |
