5CJ7
Human DNA polymerase lambda L431A mutant- MgdTTP binary and complex with 6 paired DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0034061 | molecular_function | DNA polymerase activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0006281 | biological_process | DNA repair |
| B | 0034061 | molecular_function | DNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | ASP427 |
| B | ASP429 |
| B | TTP602 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue TTP B 602 |
| Chain | Residue |
| B | ASP429 |
| B | TYR505 |
| B | PHE506 |
| B | THR507 |
| B | GLY508 |
| B | ALA510 |
| B | ASN513 |
| B | MG601 |
| B | ARG386 |
| B | GLY416 |
| B | SER417 |
| B | ARG420 |
| B | GLY426 |
| B | ASP427 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 |
| Chain | Residue | Details |
| A | LYS312 | |
| B | LYS312 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ |
| Chain | Residue | Details |
| A | ARG386 | |
| A | SER417 | |
| A | GLY426 | |
| A | ASN513 | |
| B | ARG386 | |
| B | SER417 | |
| B | GLY426 | |
| B | ASN513 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ |
| Chain | Residue | Details |
| A | ASP427 | |
| A | ASP429 | |
| A | ASP490 | |
| B | ASP427 | |
| B | ASP429 | |
| B | ASP490 |
