5CHV
Crystal structure of USP18-ISG15 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Ubl carboxyl-terminal hydrolase 18 | polymer | 323 | 37353.0 | 2 | UniProt (Q9WTV6) Pfam (PF00443) | Mus musculus (Mouse) | 43 kDa ISG15-specific protease,ISG15-specific-processing protease,Ubl thioesterase 18 |
| 2 | B, D (C, D) | Ubiquitin-like protein ISG15 | polymer | 155 | 17354.0 | 2 | UniProt (Q64339) Pfam (PF00240) | Mus musculus (Mouse) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein |
| 3 | E, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, I (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | G, J (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | K, L, M (A, C, B) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 155 (UniProt: Q64339)
| PDB | External Database | Details |
|---|---|---|
| Ser 76 | Cys 76 | engineered mutation |
| Aye 155 | Gly 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 109414.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 393.9 | |
| All* | Total formula weight | 109808.0 |
