5CCH

Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Vesicle-associated membrane protein 2	polymer	63	7231.1	1	UniProt (P63045) Pfam (PF00957) In PDB	Rattus norvegicus (Rat)	VAMP-2,Synaptobrevin-2
2	B	Syntaxin-1A	polymer	67	7838.0	1	UniProt (P32851) Pfam (PF05739) In PDB	Rattus norvegicus (Rat)	Neuron-specific antigen HPC-1,Synaptotagmin-associated 35 kDa protein,P35A
3	C	Synaptosomal-associated protein 25	polymer	77	9030.1	1	UniProt (P60881) In PDB	Rattus norvegicus (Rat)	SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein
4	D	Synaptosomal-associated protein 25	polymer	65	7471.4	1	UniProt (P60881) In PDB	Rattus norvegicus (Rat)	SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein
5	E, F	Synaptotagmin-1	polymer	281	32247.2	2	UniProt (P21707) Pfam (PF00168) In PDB	Rattus norvegicus (Rat)	Synaptotagmin I,SytI,p65
6	E, F	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)

Sequence modifications

A: 28 - 89 (UniProt: P63045)

PDB	External Database	Details
Gly 27	-	expression tag

B: 191 - 256 (UniProt: P32851)

PDB	External Database	Details
Met 190	-	initiating methionine

D: 141 - 204 (UniProt: P60881)

PDB	External Database	Details
Met 140	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96064.9
Non-Polymers*	Number of molecules	7
	Total formula weight	280.5
All*	Total formula weight	96345.4

*Water molecules are not included.