5C01

Crystal Structure of kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2	polymer	342	38475.5	2	UniProt (P29597) Pfam (PF07714)	Homo sapiens
2	C, G (A, B)	UNKNOWN LIGAND	non-polymer			2	Chemie (UNL)
3	D, E, H (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	F (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	I, J (A, B)	water	water		18.0	245	Chemie (HOH)

Sequence modifications

A, B: 556 - 871 (UniProt: P29597)

PDB	External Database	Details
Met 530	-	expression tag
Ser 531	-	expression tag
Tyr 532	-	expression tag
Tyr 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
Asp 540	-	expression tag
Tyr 541	-	expression tag
Asp 542	-	expression tag
Ile 543	-	expression tag
Pro 544	-	expression tag
Thr 545	-	expression tag
Thr 546	-	expression tag
Glu 547	-	expression tag
Asn 548	-	expression tag
Leu 549	-	expression tag
Tyr 550	-	expression tag
Phe 551	-	expression tag
Gln 552	-	expression tag
Gly 553	-	expression tag
Ala 554	-	expression tag
Met 555	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76951.1
Non-Polymers*	Number of molecules	6
	Total formula weight	278.3
All*	Total formula weight	77229.4

*Water molecules are not included.