5BK8

Cancer-associated SHP2/T507K mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 11	polymer	536	61789.7	1	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (Human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
2	B (A)	water	water		18.0	231	Chemie (HOH)

Sequence modifications

A: 1 - 528 (UniProt: Q06124)

PDB	External Database	Details
Lys 507	Thr 507	engineered mutation
Leu 529	-	expression tag
Glu 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	61789.7
All*	Total formula weight	61789.7

*Water molecules are not included.