5B4X

Crystal structure of the ApoER2 ectodomain in complex with the Reelin R56 fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Reelin	polymer	725	81786.0	2	UniProt (Q60841) Pfam (PF21471)	Mus musculus (Mouse)	Reeler protein
2	B, D (B, D)	Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, isoform CRA_e	polymer	570	63649.1	2	UniProt (D3DQ39) Pfam (PF07645) Pfam (PF00058) Pfam (PF00057) Pfam (PF14670) UniProt (by SIFTS) (Q14114)	Homo sapiens (Human)	LRP-8,Apolipoprotein E receptor 2
3	E, F, G, H, K... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	16	Chemie (CA)
4	I, J, O, T, Y (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)

Sequence modifications

A, C: 1948 - 2662 (UniProt: Q60841)

PDB	External Database	Details
Gly 1946	-	expression tag
Arg 1947	-	expression tag
Ala 2101	Cys 2101	engineered mutation
Arg 2663	-	expression tag
Leu 2664	-	expression tag
Glu 2665	-	expression tag
Asn 2666	-	expression tag
Leu 2667	-	expression tag
Tyr 2668	-	expression tag
Phe 2669	-	expression tag
Gln 2670	-	expression tag

B, D: 41 - 606 (UniProt: D3DQ39)

PDB	External Database	Details
Ser 40	-	expression tag
Ala 607	-	expression tag
Ser 608	-	expression tag
Ser 609	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	290870.3
Non-Polymers*	Number of molecules	21
	Total formula weight	1747.3
All*	Total formula weight	292617.6

*Water molecules are not included.