5AO0
Crystal structure of human SAMHD1 (amino acid residues 41-583) bound to ddGTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 | polymer | 565 | 65383.8 | 2 | UniProt (Q9Y3Z3) Pfam (PF07647) Pfam (PF01966) In PDB | HOMO SAPIENS (HUMAN) | DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1, SAMHD1 |
| 2 | A, B | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 3 | A, B | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 491.2 | 4 | Chemie (DG3) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: 41 - 583 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | expression tag |
| Ala 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Trp 22 | - | expression tag |
| Ser 23 | - | expression tag |
| His 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Gln 26 | - | expression tag |
| Phe 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Lys 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Leu 32 | - | expression tag |
| Glu 33 | - | expression tag |
| Val 34 | - | expression tag |
| Leu 35 | - | expression tag |
| Phe 36 | - | expression tag |
| Gln 37 | - | expression tag |
| Gly 38 | - | expression tag |
| Pro 39 | - | expression tag |
| Gly 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 130767.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2125.0 | |
| All* | Total formula weight | 132892.6 |
