5AO0
Crystal structure of human SAMHD1 (amino acid residues 41-583) bound to ddGTP
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE A 1001 |
Chain | Residue |
A | HIS167 |
A | HIS206 |
A | ASP207 |
A | ASP311 |
A | DG32001 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE DG3 A 2001 |
Chain | Residue |
A | HIS210 |
A | HIS215 |
A | HIS233 |
A | ASP311 |
A | LYS312 |
A | TYR315 |
A | TYR374 |
A | ASN380 |
A | FE1001 |
A | ARG164 |
A | HIS167 |
A | HIS206 |
A | ASP207 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE DG3 A 2002 |
Chain | Residue |
A | LYS116 |
A | ILE118 |
A | ASP137 |
A | GLN142 |
A | ARG145 |
A | PHE165 |
A | MG3001 |
A | HOH4002 |
B | TYR155 |
B | VAL156 |
B | VAL378 |
B | ARG451 |
B | LEU453 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG A 3001 |
Chain | Residue |
A | DG32002 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE B 1001 |
Chain | Residue |
B | HIS167 |
B | HIS206 |
B | ASP207 |
B | ASP311 |
B | DG32001 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE DG3 B 2001 |
Chain | Residue |
B | ARG164 |
B | HIS167 |
B | HIS206 |
B | ASP207 |
B | HIS210 |
B | HIS215 |
B | HIS233 |
B | ASP311 |
B | TYR315 |
B | HIS370 |
B | TYR374 |
B | ASN380 |
B | FE1001 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE DG3 B 2002 |
Chain | Residue |
A | TYR155 |
A | VAL156 |
A | VAL378 |
A | ARG451 |
A | LEU453 |
B | LYS116 |
B | VAL117 |
B | ILE118 |
B | ILE136 |
B | ASP137 |
B | GLN142 |
B | ARG145 |
B | PHE165 |
B | MG3001 |
B | HOH4001 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 3001 |
Chain | Residue |
B | DG32002 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:22056990 |
Chain | Residue | Details |
A | HIS233 | |
B | HIS233 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: in other chain => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | LYS116 | |
B | ARG352 | |
B | ASN358 | |
B | LYS523 | |
A | ASP137 | |
A | ARG333 | |
A | ARG352 | |
A | ASN358 | |
A | LYS523 | |
B | LYS116 | |
B | ASP137 | |
B | ARG333 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | ASN119 | |
B | LYS455 | |
A | HIS376 | |
A | LYS377 | |
A | ARG451 | |
A | LYS455 | |
B | ASN119 | |
B | HIS376 | |
B | LYS377 | |
B | ARG451 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705 |
Chain | Residue | Details |
A | GLN149 | |
B | ARG164 | |
B | HIS210 | |
B | ASP309 | |
B | TYR315 | |
B | ASP319 | |
B | ARG366 | |
B | HIS370 | |
A | ARG164 | |
A | HIS210 | |
A | ASP309 | |
A | TYR315 | |
A | ASP319 | |
A | ARG366 | |
A | HIS370 | |
B | GLN149 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26431200 |
Chain | Residue | Details |
A | HIS167 | |
A | HIS206 | |
A | ASP207 | |
A | ASP311 | |
B | HIS167 | |
B | HIS206 | |
B | ASP207 | |
B | ASP311 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER93 | |
B | SER93 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS467 | |
A | LYS469 | |
A | LYS492 | |
B | LYS467 | |
B | LYS469 | |
B | LYS492 |