5AJP
Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 | polymer | 571 | 64824.7 | 1 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) | HOMO SAPIENS | POLYPEPTIDE GALNAC TRANSFERASE 2, GALNAC-T2, PP-GANTASE 2, PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE 2, UDP-GALNAC\:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 SOLUBLE FORM |
| 2 | B (B) | MUCIN | polymer | 17 | 1546.6 | 1 | UniProt (Q14886) UniProt (by SIFTS) (P98088) | HOMO SAPIENS (HUMAN) | |
| 3 | C (A) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 1 | Chemie (UDP) | |||
| 4 | D, F, G, H, I... (A) | SULFATE ION | non-polymer | 96.1 | 21 | Chemie (SO4) | |||
| 5 | E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 6 | Z (B) | 2-acetamido-2-deoxy-alpha-D-galactopyranose | non-polymer | 221.2 | 1 | Chemie (A2G) | |||
| 7 | AA, BA (A, B) | water | water | 18.0 | 611 | Chemie (HOH) |
Sequence modifications
A: 1 - 571 (UniProt: Q10471)
B: 1 - 15 (UniProt: Q14886)
| PDB | External Database | Details |
|---|---|---|
| Asp 516 | Asn 516 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| Ala 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66371.3 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2697.6 | |
| All* | Total formula weight | 69069.0 |
