5AJP
Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0005795 | cellular_component | Golgi stack |
A | 0006486 | biological_process | protein glycosylation |
A | 0006493 | biological_process | protein O-linked glycosylation |
A | 0016020 | cellular_component | membrane |
A | 0016266 | biological_process | O-glycan processing |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0018242 | biological_process | protein O-linked glycosylation via serine |
A | 0018243 | biological_process | protein O-linked glycosylation via threonine |
A | 0030145 | molecular_function | manganese ion binding |
A | 0030246 | molecular_function | carbohydrate binding |
A | 0032580 | cellular_component | Golgi cisterna membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0051604 | biological_process | protein maturation |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:25939779, ECO:0007744|PDB:5AJO |
Chain | Residue | Details |
B | THR3 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (GalNAc) threonine => ECO:0000269|PubMed:25939779, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP |
Chain | Residue | Details |
B | THR13 |
site_id | SWS_FT_FI3 |
Number of Residues | 546 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
A | SER25-GLN571 |
site_id | SWS_FT_FI4 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
Chain | Residue | Details |
A | THR143 | |
A | ASP176 | |
A | ARG201 | |
A | SER225 | |
A | TRP331 | |
A | ARG362 | |
A | HIS365 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
Chain | Residue | Details |
A | ASP224 | |
A | HIS226 | |
A | HIS359 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJN, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9, ECO:0007744|PDB:5NDF, ECO:0007744|PDB:6EGS |
Chain | Residue | Details |
A | TYR367 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Not glycosylated |
Chain | Residue | Details |
A | ASP516 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER536 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:37453717 |
Chain | Residue | Details |
A | SER29 |