5AEK

Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	SENTRIN-SPECIFIC PROTEASE 2	polymer	224	26542.8	12	UniProt (Q9HC62) Pfam (PF02902)	HOMO SAPIENS (HUMAN)	AXAM2, SMT3-SPECIFIC ISOPEPTIDASE 2, SMT3IP2, SENTRIN/SUMO-SPECIFIC PROTEASE SENP2
2	B, D, F, H, J... (B, D, F, H, J...)	SMALL UBIQUITIN-RELATED MODIFIER 1	polymer	78	9140.4	12	UniProt (P63165) Pfam (PF11976)	HOMO SAPIENS (HUMAN)	SUMO-1, GAP-MODIFYING PROTEIN 1, GMP1, SMT3 HOMOLOG 3, SENT RIN, UBIQUITIN-HOMOLOGY DOMAIN PROTEIN PIC1, UBIQUITIN-LIKE PROTEI N SMT3C, SMT3C, UBIQUITIN-LIKE PROTEIN UBL1

Sequence modifications

A, C, E, G, I, K, M, O, Q, S, U, W: 366 - 589 (UniProt: Q9HC62)

PDB	External Database	Details
Ser 548	Cys 548	engineered mutation

B, D, F, H, J, L, N, P, R, T, V, X: 20 - 97 (UniProt: P63165)

PDB	External Database	Details
Met 48	Lys 48	engineered mutation
Trp 66	Phe 66	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	428198.3
All*	Total formula weight	428198.3

*Water molecules are not included.