5AEK
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008234 | molecular_function | cysteine-type peptidase activity |
E | 0006508 | biological_process | proteolysis |
E | 0008234 | molecular_function | cysteine-type peptidase activity |
G | 0006508 | biological_process | proteolysis |
G | 0008234 | molecular_function | cysteine-type peptidase activity |
I | 0006508 | biological_process | proteolysis |
I | 0008234 | molecular_function | cysteine-type peptidase activity |
K | 0006508 | biological_process | proteolysis |
K | 0008234 | molecular_function | cysteine-type peptidase activity |
M | 0006508 | biological_process | proteolysis |
M | 0008234 | molecular_function | cysteine-type peptidase activity |
O | 0006508 | biological_process | proteolysis |
O | 0008234 | molecular_function | cysteine-type peptidase activity |
Q | 0006508 | biological_process | proteolysis |
Q | 0008234 | molecular_function | cysteine-type peptidase activity |
S | 0006508 | biological_process | proteolysis |
S | 0008234 | molecular_function | cysteine-type peptidase activity |
U | 0006508 | biological_process | proteolysis |
U | 0008234 | molecular_function | cysteine-type peptidase activity |
W | 0006508 | biological_process | proteolysis |
W | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | SITE: Interaction with PIAS2 |
Chain | Residue | Details |
B | PHE36 | |
T | PHE36 | |
V | PHE36 | |
X | PHE36 | |
M | HIS478 | |
M | ASP495 | |
O | HIS478 | |
O | ASP495 | |
Q | HIS478 | |
Q | ASP495 | |
S | HIS478 | |
D | PHE36 | |
S | ASP495 | |
U | HIS478 | |
U | ASP495 | |
W | HIS478 | |
W | ASP495 | |
F | PHE36 | |
H | PHE36 | |
J | PHE36 | |
L | PHE36 | |
N | PHE36 | |
P | PHE36 | |
R | PHE36 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER32 | |
T | SER32 | |
V | SER32 | |
X | SER32 | |
D | SER32 | |
F | SER32 | |
H | SER32 | |
J | SER32 | |
L | SER32 | |
N | SER32 | |
P | SER32 | |
R | SER32 |
site_id | SWS_FT_FI3 |
Number of Residues | 48 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
B | LYS23 | |
F | LYS39 | |
F | LYS45 | |
F | LYS46 | |
H | LYS23 | |
H | LYS39 | |
H | LYS45 | |
H | LYS46 | |
J | LYS23 | |
J | LYS39 | |
J | LYS45 | |
B | LYS39 | |
J | LYS46 | |
L | LYS23 | |
L | LYS39 | |
L | LYS45 | |
L | LYS46 | |
N | LYS23 | |
N | LYS39 | |
N | LYS45 | |
N | LYS46 | |
P | LYS23 | |
B | LYS45 | |
P | LYS39 | |
P | LYS45 | |
P | LYS46 | |
R | LYS23 | |
R | LYS39 | |
R | LYS45 | |
R | LYS46 | |
T | LYS23 | |
T | LYS39 | |
T | LYS45 | |
B | LYS46 | |
T | LYS46 | |
V | LYS23 | |
V | LYS39 | |
V | LYS45 | |
V | LYS46 | |
X | LYS23 | |
X | LYS39 | |
X | LYS45 | |
X | LYS46 | |
D | LYS23 | |
D | LYS39 | |
D | LYS45 | |
D | LYS46 | |
F | LYS23 |
site_id | SWS_FT_FI4 |
Number of Residues | 24 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000269|PubMed:27068747 |
Chain | Residue | Details |
J | GLY97 | |
L | GLY97 | |
N | GLY97 | |
P | GLY97 | |
R | GLY97 | |
B | GLY97 | |
T | GLY97 | |
V | GLY97 | |
X | GLY97 | |
D | GLY97 | |
F | GLY97 | |
H | GLY97 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) |
Chain | Residue | Details |
B | LYS25 | |
T | LYS25 | |
V | LYS25 | |
X | LYS25 | |
D | LYS25 | |
F | LYS25 | |
H | LYS25 | |
J | LYS25 | |
L | LYS25 | |
N | LYS25 | |
P | LYS25 | |
R | LYS25 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
B | LYS37 | |
T | LYS37 | |
V | LYS37 | |
X | LYS37 | |
D | LYS37 | |
F | LYS37 | |
H | LYS37 | |
J | LYS37 | |
L | LYS37 | |
N | LYS37 | |
P | LYS37 | |
R | LYS37 |