5AEK
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008234 | molecular_function | cysteine-type peptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008234 | molecular_function | cysteine-type peptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0008234 | molecular_function | cysteine-type peptidase activity |
| M | 0006508 | biological_process | proteolysis |
| M | 0008234 | molecular_function | cysteine-type peptidase activity |
| O | 0006508 | biological_process | proteolysis |
| O | 0008234 | molecular_function | cysteine-type peptidase activity |
| Q | 0006508 | biological_process | proteolysis |
| Q | 0008234 | molecular_function | cysteine-type peptidase activity |
| S | 0006508 | biological_process | proteolysis |
| S | 0008234 | molecular_function | cysteine-type peptidase activity |
| U | 0006508 | biological_process | proteolysis |
| U | 0008234 | molecular_function | cysteine-type peptidase activity |
| W | 0006508 | biological_process | proteolysis |
| W | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1968 |
| Details | Region: {"description":"Protease","evidences":[{"source":"PubMed","id":"15296745","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15296745","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15296745","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 770 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Region: {"description":"(Microbial infection) Interaction with Tula hantavirus","evidences":[{"source":"PubMed","id":"12606074","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Site: {"description":"Interaction with PIAS2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PubMed","id":"27068747","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
