5AEK
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008234 | molecular_function | cysteine-type peptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008234 | molecular_function | cysteine-type peptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0008234 | molecular_function | cysteine-type peptidase activity |
| M | 0006508 | biological_process | proteolysis |
| M | 0008234 | molecular_function | cysteine-type peptidase activity |
| O | 0006508 | biological_process | proteolysis |
| O | 0008234 | molecular_function | cysteine-type peptidase activity |
| Q | 0006508 | biological_process | proteolysis |
| Q | 0008234 | molecular_function | cysteine-type peptidase activity |
| S | 0006508 | biological_process | proteolysis |
| S | 0008234 | molecular_function | cysteine-type peptidase activity |
| U | 0006508 | biological_process | proteolysis |
| U | 0008234 | molecular_function | cysteine-type peptidase activity |
| W | 0006508 | biological_process | proteolysis |
| W | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | SITE: Interaction with PIAS2 |
| Chain | Residue | Details |
| B | PHE36 | |
| T | PHE36 | |
| V | PHE36 | |
| X | PHE36 | |
| M | HIS478 | |
| M | ASP495 | |
| O | HIS478 | |
| O | ASP495 | |
| Q | HIS478 | |
| Q | ASP495 | |
| S | HIS478 | |
| D | PHE36 | |
| S | ASP495 | |
| U | HIS478 | |
| U | ASP495 | |
| W | HIS478 | |
| W | ASP495 | |
| F | PHE36 | |
| H | PHE36 | |
| J | PHE36 | |
| L | PHE36 | |
| N | PHE36 | |
| P | PHE36 | |
| R | PHE36 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER32 | |
| T | SER32 | |
| V | SER32 | |
| X | SER32 | |
| D | SER32 | |
| F | SER32 | |
| H | SER32 | |
| J | SER32 | |
| L | SER32 | |
| N | SER32 | |
| P | SER32 | |
| R | SER32 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS23 | |
| F | LYS39 | |
| F | LYS45 | |
| F | LYS46 | |
| H | LYS23 | |
| H | LYS39 | |
| H | LYS45 | |
| H | LYS46 | |
| J | LYS23 | |
| J | LYS39 | |
| J | LYS45 | |
| B | LYS39 | |
| J | LYS46 | |
| L | LYS23 | |
| L | LYS39 | |
| L | LYS45 | |
| L | LYS46 | |
| N | LYS23 | |
| N | LYS39 | |
| N | LYS45 | |
| N | LYS46 | |
| P | LYS23 | |
| B | LYS45 | |
| P | LYS39 | |
| P | LYS45 | |
| P | LYS46 | |
| R | LYS23 | |
| R | LYS39 | |
| R | LYS45 | |
| R | LYS46 | |
| T | LYS23 | |
| T | LYS39 | |
| T | LYS45 | |
| B | LYS46 | |
| T | LYS46 | |
| V | LYS23 | |
| V | LYS39 | |
| V | LYS45 | |
| V | LYS46 | |
| X | LYS23 | |
| X | LYS39 | |
| X | LYS45 | |
| X | LYS46 | |
| D | LYS23 | |
| D | LYS39 | |
| D | LYS45 | |
| D | LYS46 | |
| F | LYS23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000269|PubMed:27068747 |
| Chain | Residue | Details |
| J | GLY97 | |
| L | GLY97 | |
| N | GLY97 | |
| P | GLY97 | |
| R | GLY97 | |
| B | GLY97 | |
| T | GLY97 | |
| V | GLY97 | |
| X | GLY97 | |
| D | GLY97 | |
| F | GLY97 | |
| H | GLY97 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) |
| Chain | Residue | Details |
| B | LYS25 | |
| T | LYS25 | |
| V | LYS25 | |
| X | LYS25 | |
| D | LYS25 | |
| F | LYS25 | |
| H | LYS25 | |
| J | LYS25 | |
| L | LYS25 | |
| N | LYS25 | |
| P | LYS25 | |
| R | LYS25 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS37 | |
| T | LYS37 | |
| V | LYS37 | |
| X | LYS37 | |
| D | LYS37 | |
| F | LYS37 | |
| H | LYS37 | |
| J | LYS37 | |
| L | LYS37 | |
| N | LYS37 | |
| P | LYS37 | |
| R | LYS37 |
