5A3I

Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	HEMAGGLUTININ	polymer	328	37176.1	2	UniProt (A5A5M5) UniProt (by SIFTS) (Q6DQ33)	INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)) (INFLUENZA VIRUS)	HAEMAGGLUTININ HA1
2	B (B)	HEMAGGLUTININ	polymer	166	19098.0	1	UniProt (A5A5M5) UniProt (by SIFTS) (A8UDR1)	INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)) (INFLUENZA VIRUS)	HAEMAGGLUTININ HA1
3	C, G (C, G)	ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN	polymer	230	24630.7	2		HOMO SAPIENS (HUMAN)
4	D, H (D, H)	ANTI-HAEMAGGLUTININ HA1 FAB LIGHT CHAIN	polymer	219	23830.6	2		HOMO SAPIENS (HUMAN)
5	F (F)	HEMAGGLUTININ	polymer	166	19070.0	1	UniProt (A5A5M5) UniProt (by SIFTS) (A8UDR1)	INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)) (INFLUENZA VIRUS)	HAEMAGGLUTININ HA1
6	I, J (I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	K (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A, E: 1 - 324 (UniProt: A5A5M5)

PDB	External Database	Details
Asp -1	-	expression tag
Pro 0	-	expression tag
Thr 325	-	expression tag
Arg 326	-	expression tag
Asp 154	Asn 170	conflict
Lys 220	Asn 236	conflict
Leu 222	Gln 238	conflict
Ile 315	Thr 331	conflict

F: 1 - 166 (UniProt: A5A5M5)

PDB	External Database	Details
Lys 68	Arg 414	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	209442.8
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	210512.8

*Water molecules are not included.