4ZPK

Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Aryl hydrocarbon receptor nuclear translocator	polymer	384	43437.4	1	UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598)	Mus musculus (Mouse)	ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta
2	B (B)	Endothelial PAS domain-containing protein 1	polymer	360	41201.0	1	UniProt (P97481) Pfam (PF00989) Pfam (PF14598)	Mus musculus (Mouse)	EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF2-alpha
3	C (C)	DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3')	polymer	21	6527.2	1		Mus musculus
4	D (D)	DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3')	polymer	21	6363.1	1		Mus musculus

Sequence modifications

A: 82 - 464 (UniProt: P53762)

PDB	External Database	Details
Met 81	-	initiating methionine

B: 3 - 361 (UniProt: P97481)

PDB	External Database	Details
Met 2	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	97528.6
All*	Total formula weight	97528.6

*Water molecules are not included.