4ZPK
Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005667 | cellular_component | transcription regulator complex |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"bHLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00981","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"26245371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28602820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Mediates the transcription activity and dimerization of the AHR:ARNT complex","evidences":[{"source":"PubMed","id":"24001774","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 70 |
| Details | Domain: {"description":"PAS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00140","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"26245371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Region: {"description":"Required for heterodimer formation with ARNT","evidences":[{"source":"PubMed","id":"26245371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
