4ZOK
Methylsulfonyl-containing inhibitor bound in the substrate capture site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Anthranilate phosphoribosyltransferase | polymer | 379 | 38948.0 | 2 | UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) | Mycobacterium tuberculosis H37Ra | |
| 2 | C, D, G, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | E, I (A, B) | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose | non-polymer | 390.1 | 2 | Chemie (PRP) | |||
| 4 | F (A) | 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid | non-polymer | 319.4 | 1 | Chemie (62L) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 370 (UniProt: A5U4M0)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Val 1 | - | cloning artifact |
| Leu 371 | - | expression tag |
| Glu 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| His 377 | - | expression tag |
| His 378 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77896.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1196.7 | |
| All* | Total formula weight | 79092.8 |
