4ZLY

Crystal Structure of Bruton's Tyrosine Kinase bound to a Cinnoline Fragment

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
ATyrosine-protein kinase BTKpolymer27031511.21
UniProt (Q06187)
Pfam (PF07714)
Homo sapiens (Human)@PDBjAgammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase
IMIDAZOLEnon-polymer69.12
ISOPROPYL ALCOHOLnon-polymer60.11
DIMETHYL SULFOXIDEnon-polymer78.11
4-aminocinnoline-3-carboxamidenon-polymer188.21
waterwater18.0382

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains1
Total molecular weight31511.2
Non-Polymers*Number of molecules5
Total molecular weight464.6
All*Total molecular weight31975.8
*Water molecules are not included.