4ZLY
Crystal Structure of Bruton's Tyrosine Kinase bound to a Cinnoline Fragment
Summary for 4ZLY
Entry DOI | 10.2210/pdb4zly/pdb |
Related | 4ZLZ |
Descriptor | Tyrosine-protein kinase BTK, IMIDAZOLE, ISOPROPYL ALCOHOL, ... (6 entities in total) |
Functional Keywords | cytoplasmic tyrosine kinase, transcriptional regulation, nuclear factor-kappab, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 31975.79 |
Authors | Dougan, D.R. (deposition date: 2015-05-01, release date: 2015-07-01, Last modification date: 2024-03-06) |
Primary citation | Smith, C.R.,Dougan, D.R.,Komandla, M.,Kanouni, T.,Knight, B.,Lawson, J.D.,Sabat, M.,Taylor, E.R.,Vu, P.,Wyrick, C. Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 58:5437-5444, 2015 Cited by PubMed: 26087137DOI: 10.1021/acs.jmedchem.5b00734 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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