4ZCH

Single-chain human APRIL-BAFF-BAFF Heterotrimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B	polymer	438	48731.4	2	UniProt (O75888) UniProt (Q9Y275) Pfam (PF00229)	Homo sapiens (Human)	A proliferation-inducing ligand,APRIL,TNF- and APOL-related leukocyte expressed ligand 2,TALL-2,TNF-related death ligand 1,TRDL-1,B lymphocyte stimulator,BLyS,B-cell-activating factor,BAFF,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1,TALL-1,B lymphocyte stimulator,BLyS,B-cell-activating factor,BAFF,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1,TALL-1
2	C (A)	TRIS-HYDROXYMETHYL-METHYL-AMMONIUM	non-polymer		122.1	1	Chemie (144)
3	D, E (A, B)	water	water		18.0	339	Chemie (HOH)

Sequence modifications

A, B: 7 - 142 (UniProt: O75888)

PDB	External Database	Details
Ala 18	Thr 98	conflict
Gly 143	-	linker
Gly 144	-	linker
Gly 145	-	linker
Gly 146	-	linker
Ser 147	-	linker

A, B: 148 - 293 (UniProt: Q9Y275)
A, B: 299 - 444 (UniProt: Q9Y275)

PDB	External Database	Details
Gly 294	-	linker
Gly 295	-	linker
Gly 296	-	linker
Gly 297	-	linker
Ser 298	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	97462.9
Non-Polymers*	Number of molecules	1
	Total formula weight	122.1
All*	Total formula weight	97585.0

*Water molecules are not included.