4Z6A
Crystal Structure of a FVIIa-Trypsin Chimera (YT) in Complex with Soluble Tissue Factor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L | Coagulation factor VII | polymer | 96 | 10500.7 | 1 | UniProt (P08709) Pfam (PF00008) Pfam (PF14670) In PDB | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
2 | H | Coagulation factor VII | polymer | 249 | 27524.6 | 1 | UniProt (P08709) Pfam (PF00089) In PDB | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
3 | T | Tissue factor | polymer | 207 | 23518.2 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) In PDB | Homo sapiens (Human) | TF,Coagulation factor III,Thromboplastin |
4 | L | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
5 | L | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
6 | H | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide | non-polymer | 504.0 | 1 | BIRD (PRD_000369) Chemie (0Z6) | Proconvertin,Serum prothrombin conversion accelerator,SPCA | ||
7 | H | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
8 | T | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
9 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
H: 16 - 257 (UniProt: P08709)
PDB | External Database | Details |
---|---|---|
- | Leu 371 | deletion |
- | Gln 372 | deletion |
- | Gln 373 | deletion |
- | Ser 374 | deletion |
- | Arg 375 | deletion |
Glu 169 | Lys 376 | engineered mutation |
Ala 170 | Val 377 | engineered mutation |
Ser 171 | Gly 378 | engineered mutation |
Tyr 172 | Asp 379 | engineered mutation |
Pro 173 | Ser 380 | engineered mutation |
Gly 174 | Pro 381 | engineered mutation |
Lys 175 | Asn 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 61543.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1080.6 | |
All* | Total formula weight | 62624.1 |