4Z50

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20D25N with Tucked Flap

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Protease	polymer	99	10765.6	4	UniProt (Q0PQ60) Pfam (PF00077) In PDB	Human immunodeficiency virus 1
2	A, B, C, D	CHLORIDE ION	non-polymer		35.5	9	Chemie (CL)
3	B, C, D	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
4	B, D	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	400	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 99 (UniProt: Q0PQ60)

PDB	External Database	Details
Lys 7	Gln 7	engineered mutation
Asn 25	Asp 25	engineered mutation
Ile 32	Val 32	engineered mutation
Asn 37	Glu 37	engineered mutation
Val 47	Ile 47	engineered mutation
Leu 54	Val 54	engineered mutation
Glu 58	Gln 58	engineered mutation
Ala 67	Cys 67	engineered mutation
Val 71	Ala 71	engineered mutation
Thr 89	Phe 89	engineered mutation
Ile 93	Leu 93	engineered mutation
Ala 95	Cys 95	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	43062.2
Non-Polymers*	Number of molecules	15
	Total formula weight	595.2
All*	Total formula weight	43657.5

*Water molecules are not included.