4Z50

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20D25N with Tucked Flap

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0016787	molecular_function	hydrolase activity
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL A 101

Chain	Residue
A	GLU21

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL B 201

Chain	Residue
B	LYS155
D	TRP106

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site_id	AC3
Number of Residues	2
Details	binding site for residue CL B 202

Chain	Residue
B	GLU121
B	HOH378

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL B 203

Chain	Residue
B	LYS107
B	ARG108

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site_id	AC5
Number of Residues	6
Details	binding site for residue NA B 204

Chain	Residue
B	HOH306
B	HOH349
B	HOH363
B	HOH386
B	ASP160
B	HOH305

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site_id	AC6
Number of Residues	1
Details	binding site for residue NA B 205

Chain	Residue
B	LEU119

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site_id	AC7
Number of Residues	4
Details	binding site for residue GOL B 206

Chain	Residue
B	THR112
B	GLU165
B	ALA167
B	GLY168

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site_id	AC8
Number of Residues	3
Details	binding site for residue CL C 101

Chain	Residue
C	LYS7
C	ARG8
C	HOH227

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site_id	AC9
Number of Residues	1
Details	binding site for residue CL C 102

Chain	Residue
C	GLU21

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site_id	AD1
Number of Residues	1
Details	binding site for residue CL C 103

Chain	Residue
C	ARG8

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site_id	AD2
Number of Residues	5
Details	binding site for residue NA C 104

Chain	Residue
C	ASP60
C	HOH218
C	HOH243
C	HOH255
C	HOH265

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site_id	AD3
Number of Residues	1
Details	binding site for residue CL D 201

Chain	Residue
D	GLU121

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site_id	AD4
Number of Residues	3
Details	binding site for residue CL D 202

Chain	Residue
D	LYS107
D	ARG108
D	HOH366

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site_id	AD5
Number of Residues	7
Details	binding site for residue NA D 203

Chain	Residue
D	ASP160
D	HOH302
D	HOH324
D	HOH349
D	HOH364
D	HOH380
D	HOH390

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site_id	AD6
Number of Residues	6
Details	binding site for residue GOL D 204

Chain	Residue
A	HOH270
D	HIS169
D	GLN192
D	ILE193
D	HOH308
D	HOH326

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