4YPG
Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (A, L) | Sifalimumab light chain | polymer | 215 | 23432.0 | 2 | UniProt (Q6PJF2) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B, E (B, H) | Sifalimumab heavy chain | polymer | 219 | 23217.0 | 2 | Homo sapiens (Human) | ||
| 3 | C, D (C, D) | Interferon alpha-2 | polymer | 161 | 18749.5 | 2 | UniProt (P01563) Pfam (PF00143) | Homo sapiens (Human) | IFN-alpha-2,Interferon alpha-A,LeIF A |
| 4 | G, H, I, J, K... (A, B, C, D, H...) | NICKEL (II) ION | non-polymer | 58.7 | 6 | Chemie (NI) | |||
| 5 | M, N, O, P, Q... (A, B, C, D, H...) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, L: 1 - 215 (UniProt: Q6PJF2)
C, D: 1 - 159 (UniProt: P01563)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | Ala 29 | conflict |
| Ser 28 | Ile 48 | conflict |
| Thr 32 | Ala 52 | conflict |
| Ile 49 | Met 69 | conflict |
| Tyr 50 | Phe 70 | conflict |
| Ala 52 | Ser 72 | conflict |
| Pro 96 | Gln 116 | conflict |
| Arg 97 | Gly 117 | conflict |
| Gln 101 | Pro 121 | conflict |
| Glu 106 | Asp 126 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 130796.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 352.2 | |
| All* | Total formula weight | 131149.0 |
