4YPG

Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, L	Sifalimumab light chain	polymer	215	23432.0	2	UniProt (Q6PJF2) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	B, H	Sifalimumab heavy chain	polymer	219	23217.0	2		Homo sapiens (Human)
3	C, D	Interferon alpha-2	polymer	161	18749.5	2	UniProt (P01563) Pfam (PF00143) In PDB	Homo sapiens (Human)	IFN-alpha-2,Interferon alpha-A,LeIF A
4	A, B, C, D, H...	NICKEL (II) ION	non-polymer		58.7	6	Chemie (NI)
5		water	water		18.0	47	Chemie (HOH)

Sequence modifications

A, L: 1 - 215 (UniProt: Q6PJF2)

PDB	External Database	Details
Gly 9	Ala 29	conflict
Ser 28	Ile 48	conflict
Thr 32	Ala 52	conflict
Ile 49	Met 69	conflict
Tyr 50	Phe 70	conflict
Ala 52	Ser 72	conflict
Pro 96	Gln 116	conflict
Arg 97	Gly 117	conflict
Gln 101	Pro 121	conflict
Glu 106	Asp 126	conflict

C, D: 1 - 159 (UniProt: P01563)

PDB	External Database	Details
Thr -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	130796.9
Non-Polymers*	Number of molecules	6
	Total formula weight	352.2
All*	Total formula weight	131149.0

*Water molecules are not included.