4YPG

Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0016020	cellular_component	membrane
A	0019814	cellular_component	immunoglobulin complex
C	0002250	biological_process	adaptive immune response
C	0002286	biological_process	T cell activation involved in immune response
C	0002312	biological_process	B cell activation involved in immune response
C	0002323	biological_process	natural killer cell activation involved in immune response
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005132	molecular_function	type I interferon receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006915	biological_process	apoptotic process
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0006959	biological_process	humoral immune response
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007267	biological_process	cell-cell signaling
C	0010629	biological_process	negative regulation of gene expression
C	0031012	cellular_component	extracellular matrix
C	0032696	biological_process	negative regulation of interleukin-13 production
C	0032714	biological_process	negative regulation of interleukin-5 production
C	0043330	biological_process	response to exogenous dsRNA
C	0045581	biological_process	negative regulation of T cell differentiation
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046597	biological_process	host-mediated suppression of symbiont invasion
C	0051607	biological_process	defense response to virus
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	0098586	biological_process	cellular response to virus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
D	0002250	biological_process	adaptive immune response
D	0002286	biological_process	T cell activation involved in immune response
D	0002312	biological_process	B cell activation involved in immune response
D	0002323	biological_process	natural killer cell activation involved in immune response
D	0005125	molecular_function	cytokine activity
D	0005126	molecular_function	cytokine receptor binding
D	0005132	molecular_function	type I interferon receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0006959	biological_process	humoral immune response
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0010629	biological_process	negative regulation of gene expression
D	0031012	cellular_component	extracellular matrix
D	0032696	biological_process	negative regulation of interleukin-13 production
D	0032714	biological_process	negative regulation of interleukin-5 production
D	0043330	biological_process	response to exogenous dsRNA
D	0045581	biological_process	negative regulation of T cell differentiation
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046597	biological_process	host-mediated suppression of symbiont invasion
D	0051607	biological_process	defense response to virus
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
D	0098586	biological_process	cellular response to virus
D	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0016020	cellular_component	membrane
L	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue NI A 301

Chain	Residue
A	HIS190
A	HOH403

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site_id	AC2
Number of Residues	4
Details	binding site for residue NI B 301

Chain	Residue
B	ARG87
B	ARG87
B	ASP89
B	ASP89

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site_id	AC3
Number of Residues	4
Details	binding site for residue NI C 201

Chain	Residue
C	HIS7
C	THR-1
C	SER0
C	CYS1

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site_id	AC4
Number of Residues	4
Details	binding site for residue NI D 201

Chain	Residue
D	THR-1
D	SER0
D	CYS1
D	HIS7

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site_id	AC5
Number of Residues	4
Details	binding site for residue NI H 301

Chain	Residue
H	ARG87
H	ARG87
H	ASP89
H	ASP89

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site_id	AC6
Number of Residues	3
Details	binding site for residue NI L 301

Chain	Residue
L	HIS190
L	HOH402
L	HOH403

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Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW

Chain	Residue	Details
C	TYR122-TRP140

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR193-HIS199
B	TYR197-HIS203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","featureId":"CAR_000049","evidences":[{"source":"PubMed","id":"2049076","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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