4YL6

Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain in complex with an internal helix of mitogen-activated protein kinase kinase kinase 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Malcavernin	polymer	96	11302.8	1	UniProt (Q9BSQ5) Pfam (PF16545) In PDB	Homo sapiens (Human)	Cerebral cavernous malformations 2 protein
2	B	Mitogen-activated protein kinase kinase kinase 3	polymer	22	2594.0	1	UniProt (Q99759) In PDB	Homo sapiens	MAPK/ERK kinase kinase 3,MEKK 3
3		water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 290 - 376 (UniProt: Q9BSQ5)

PDB	External Database	Details
Met 289	-	expression tag
Leu 377	-	expression tag
Glu 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	13896.8
All*	Total formula weight	13896.8

*Water molecules are not included.