4Y6K

Complex structure of presenilin homologue PSH bound to an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Uncharacterized protein PSH	polymer	301	31879.3	4	UniProt (A3CWV0) Pfam (PF06550) In PDB	Methanoculleus marisnigri JR1
2	C, D	N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide	non-polymer		672.9	2	BIRD (PRD_002147) Chemie (4B5)

Sequence modifications

A, B, C, D: 1 - 301 (UniProt: A3CWV0)

PDB	External Database	Details
Asn 40	Asp 40	engineered mutation
Ser 42	Glu 42	engineered mutation
Glu 147	Ala 147	engineered mutation
Pro 148	Val 148	engineered mutation
Val 229	Ala 229	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127517.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1345.7
All*	Total formula weight	128862.7

*Water molecules are not included.