4Y6K

Complex structure of presenilin homologue PSH bound to an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0042500	molecular_function	aspartic endopeptidase activity, intramembrane cleaving
A	0042802	molecular_function	identical protein binding
B	0016020	cellular_component	membrane
B	0042500	molecular_function	aspartic endopeptidase activity, intramembrane cleaving
B	0042802	molecular_function	identical protein binding
C	0016020	cellular_component	membrane
C	0042500	molecular_function	aspartic endopeptidase activity, intramembrane cleaving
C	0042802	molecular_function	identical protein binding
D	0016020	cellular_component	membrane
D	0042500	molecular_function	aspartic endopeptidase activity, intramembrane cleaving
D	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 4B5 C 501

Chain	Residue
C	PHE57
C	MET216
C	ASP220
C	MET223
C	LEU275
C	ASN279
C	LEU61
C	LEU158
C	ALA159
C	TYR161
C	ASP162
C	GLU177
C	GLY212
C	VAL215

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 4B5 D 501

Chain	Residue
C	ARG71
C	PHE72
D	LEU158
D	ALA159
D	TYR161
D	ASP162
D	VAL215
D	MET216
D	MET223
D	LEU275
D	ASN279

---