4Y5Y

Diabody 330 complex with EpoR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	diabody 330 VH domain	polymer	130	13941.5	2		Homo sapiens
2	B, E (B, E)	diabody 330 VL domain	polymer	117	12016.1	2		Homo sapiens
3	C, F (C, F)	Erythropoietin receptor	polymer	229	25210.6	2	UniProt (P19235) Pfam (PF09067) Pfam (PF00041)	Homo sapiens (Human)	EPO-R
4	G (C)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	H, I, J, K, L... (A, B, C, D, E...)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

C, F: 8 - 225 (UniProt: P19235)

PDB	External Database	Details
Phe 3	-	expression tag
Ala 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag
Ala 7	-	expression tag
Gln 52	Asn 76	engineered mutation
Gln 164	Asn 188	engineered mutation
Leu 223	Asp 247	engineered mutation
Asp 224	Leu 248	engineered mutation
Lys 226	-	expression tag
Glu 227	-	expression tag
Lys 228	-	expression tag
Ala 229	-	expression tag
Ala 230	-	expression tag
Ala 231	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	102336.3
Non-Polymers*	Number of molecules	1
	Total formula weight	92.1
All*	Total formula weight	102428.4

*Water molecules are not included.