4Y5X
Diabody 305 complex with EpoR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | diabody 310 VL domain | polymer | 136 | 14222.7 | 4 | Homo sapiens | ||
| 2 | B, E, H, K (B, E, H, K) | diabody 310 VH domain | polymer | 116 | 11912.9 | 4 | UniProt (Q5NV67) Pfam (PF07686) | Homo sapiens | |
| 3 | C, F, I, L (C, F, I, L) | Erythropoietin receptor | polymer | 229 | 25129.4 | 4 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (Human) | EPO-R |
| 4 | BA, CA, DA, M, N... (L, A, B, C, E...) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 17 | Chemie (PEG) | |||
| 5 | AA (K) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 6 | EA, FA, GA, HA, IA... (A, C, D, E, F...) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
B, E, H, K: 1 - 97 (UniProt: Q5NV67)
C, F, I, L: 8 - 225 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | Arg 15 | conflict |
| Ala 21 | Ser 21 | conflict |
| Ser 35 | Asn 35 | conflict |
| Thr 46 | Lys 46 | conflict |
| Asn 53 | Asp 53 | conflict |
| Asp 98 | - | expression tag |
| Trp 99 | - | expression tag |
| Val 100 | - | expression tag |
| Phe 101 | - | expression tag |
| Gly 102 | - | expression tag |
| Gly 103 | - | expression tag |
| Gly 104 | - | expression tag |
| Thr 105 | - | expression tag |
| Lys 106 | - | expression tag |
| Val 107 | - | expression tag |
| Thr 108 | - | expression tag |
| Val 109 | - | expression tag |
| Leu 110 | - | expression tag |
| Ala 111 | - | expression tag |
| Ala 112 | - | expression tag |
| Ala 113 | - | expression tag |
| Gly 114 | - | expression tag |
| Gly 115 | - | expression tag |
| Gly 116 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Phe 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Gln 52 | Asn 76 | engineered mutation |
| Gln 164 | Asn 188 | engineered mutation |
| Lys 226 | - | expression tag |
| Glu 227 | - | expression tag |
| Lys 228 | - | expression tag |
| Ala 229 | - | expression tag |
| Ala 230 | - | expression tag |
| Ala 231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 205060.1 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1993.1 | |
| All* | Total formula weight | 207053.3 |
