4Y5X

Diabody 305 complex with EpoR

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0019814	cellular_component	immunoglobulin complex
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0005576	cellular_component	extracellular region
E	0005886	cellular_component	plasma membrane
E	0019814	cellular_component	immunoglobulin complex
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0005576	cellular_component	extracellular region
H	0005886	cellular_component	plasma membrane
H	0019814	cellular_component	immunoglobulin complex
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0005576	cellular_component	extracellular region
K	0005886	cellular_component	plasma membrane
K	0019814	cellular_component	immunoglobulin complex
L	0004896	molecular_function	cytokine receptor activity
L	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PEG A 201

Chain	Residue
A	GLY26
A	PHE27
A	ASN77

---

site_id	AC2
Number of Residues	2
Details	binding site for residue PEG B 201

Chain	Residue
B	GLN38
B	PHE63

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PEG B 202

Chain	Residue
A	LYS106
B	TRP92
B	ASP94
B	ASN97

---

site_id	AC4
Number of Residues	4
Details	binding site for residue PEG B 203

Chain	Residue
B	SER27
B	ASN31
B	ASP94
L	SER184

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PEG C 301

Chain	Residue
C	ASP159
C	TRP212

---

site_id	AC6
Number of Residues	1
Details	binding site for residue PEG C 302

Chain	Residue
C	ARG197

---

site_id	AC7
Number of Residues	1
Details	binding site for residue PEG C 303

Chain	Residue
C	ARG99

---

site_id	AC8
Number of Residues	3
Details	binding site for residue PEG E 201

Chain	Residue
E	GLN38
E	LEU40
E	PHE63

---

site_id	AC9
Number of Residues	3
Details	binding site for residue PEG F 301

Chain	Residue
F	ARG171
F	ARG197
I	ARG197

---

site_id	AD1
Number of Residues	3
Details	binding site for residue PEG G 201

Chain	Residue
G	SER54
G	ARG72
G	ASN74

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PEG G 202

Chain	Residue
G	ALA40
G	LYS43
G	GLU46
H	GLN1

---

site_id	AD3
Number of Residues	3
Details	binding site for residue PEG H 201

Chain	Residue
H	GLN38
H	PHE63
H	ASP83

---

site_id	AD4
Number of Residues	1
Details	binding site for residue PEG J 201

Chain	Residue
J	GLY9

---

site_id	AD5
Number of Residues	4
Details	binding site for residue PEG K 201

Chain	Residue
K	TRP92
K	ASP94
K	ASN97
L	PHE93

---

site_id	AD6
Number of Residues	6
Details	binding site for residue FLC K 202

Chain	Residue
K	GLN38
K	GLY58
K	SER60
K	PHE63
K	GLU82
K	ASP83

---

site_id	AD7
Number of Residues	1
Details	binding site for residue PEG L 301

Chain	Residue
L	ASP159

---

site_id	AD8
Number of Residues	1
Details	binding site for residue PEG L 302

Chain	Residue
L	HIS70

---

site_id	AD9
Number of Residues	1
Details	binding site for residue PEG L 303

Chain	Residue
L	GLN58

---

Functional Information from PROSITE/UniProt

site_id	PS01352
Number of Residues	81
Details	HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. VvLrWlpppetpmtshir...YEVdvsagqgagsvqrveilegrtecvlsnLrgrtrytfavRaRmaepsfggfWsaWsepvsL

Chain	Residue	Details
C	VAL138-LEU218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"WSXWS motif","evidences":[{"source":"PubMed","id":"9774108","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Required for ligand binding","evidences":[{"source":"PubMed","id":"8662939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---