4XX7
Crystal structure of M2A mutant of human macrophage migration inhibitory factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Macrophage migration inhibitory factor | polymer | 114 | 12294.9 | 3 | UniProt (P14174) Pfam (PF01187) | Homo sapiens (Human) | MIF,Glycosylation-inhibiting factor,GIF,L-dopachrome isomerase,L-dopachrome tautomerase,Phenylpyruvate tautomerase |
| 2 | D, F, G (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E, H (A, C) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
| 4 | I (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K, L (A, B, C) | water | water | 18.0 | 288 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 114 (UniProt: P14174)
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | Met 3 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 36884.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 500.5 | |
| All* | Total formula weight | 37385.3 |
