4XSS
Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Insulin-like growth factor I | polymer | 70 | 7663.8 | 1 | UniProt (P05019) Pfam (PF00049) | Homo sapiens (Human) | IGF-I,Mechano growth factor,MGF,Somatomedin-C |
| 2 | B (E) | Insulin receptor | polymer | 317 | 36231.8 | 1 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | IR |
| 3 | C (F) | Insulin-like growth factor receptor alpha-CT peptide | polymer | 16 | 1947.2 | 1 | UniProt (by SIFTS) (P08069) | Homo sapiens | |
| 4 | D (A) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | F (E) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | G, H, I, J (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
E: 1 - 310 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Val 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Arg 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45842.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1303.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 980.9 | |
| All* | Total formula weight | 48126.8 |
