4XP1
X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dopamine transporter, isoform B | polymer | 535 | 60020.4 | 1 | UniProt (A0A0B4KEX2) Pfam (PF00209) UniProt (by SIFTS) (Q7K4Y6) In PDB | Drosophila melanogaster (Fruit fly) | |
2 | L | Antibody fragment light chain | polymer | 214 | 23306.6 | 1 | Mus musculus | ||
3 | H | antibody fragment heavy chain | polymer | 219 | 23619.4 | 1 | Mus musculus | ||
4 | B, C | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
5 | A, L | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
8 | A | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | non-polymer | 162.2 | 1 | Chemie (P4G) | |||
9 | A | L-DOPAMINE | non-polymer | 153.2 | 1 | Chemie (LDP) | |||
10 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
11 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
12 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
13 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 25 - 600 (UniProt: A0A0B4KEX2)
PDB | External Database | Details |
---|---|---|
Ala 74 | Val 74 | engineered mutation |
- | Ser 162 | deletion |
- | Gln 163 | deletion |
- | Asn 164 | deletion |
- | Ala 165 | deletion |
- | Ser 166 | deletion |
- | Arg 167 | deletion |
- | Val 168 | deletion |
- | Pro 169 | deletion |
- | Val 170 | deletion |
- | Ile 171 | deletion |
- | Gly 172 | deletion |
- | Asn 173 | deletion |
- | Tyr 174 | deletion |
- | Ser 175 | deletion |
- | Asp 176 | deletion |
- | Leu 177 | deletion |
- | Tyr 178 | deletion |
- | Ala 179 | deletion |
- | Met 180 | deletion |
- | Gly 181 | deletion |
- | Asn 182 | deletion |
- | Gln 183 | deletion |
- | Ser 184 | deletion |
- | Leu 185 | deletion |
- | Leu 186 | deletion |
- | Tyr 187 | deletion |
- | Asn 188 | deletion |
- | Glu 189 | deletion |
- | Thr 190 | deletion |
- | Tyr 191 | deletion |
- | Met 192 | deletion |
- | Asn 193 | deletion |
- | Gly 194 | deletion |
- | Ser 195 | deletion |
- | Ser 196 | deletion |
- | Leu 197 | deletion |
- | Asp 198 | deletion |
- | Thr 199 | deletion |
- | Ser 200 | deletion |
- | Ala 201 | deletion |
- | Val 202 | deletion |
Ala 415 | Leu 415 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 106946.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 684.6 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1576.5 | |
All* | Total formula weight | 109207.5 |