4XP1
X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dopamine transporter, isoform B | polymer | 535 | 60020.4 | 1 | UniProt (A0A0B4KEX2) Pfam (PF00209) UniProt (by SIFTS) (Q7K4Y6) In PDB | Drosophila melanogaster (Fruit fly) | |
| 2 | L | Antibody fragment light chain | polymer | 214 | 23306.6 | 1 | Mus musculus | ||
| 3 | H | antibody fragment heavy chain | polymer | 219 | 23619.4 | 1 | Mus musculus | ||
| 4 | B, C | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 5 | A, L | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | A | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | non-polymer | 162.2 | 1 | Chemie (P4G) | |||
| 9 | A | L-DOPAMINE | non-polymer | 153.2 | 1 | Chemie (LDP) | |||
| 10 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 11 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 12 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 13 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 25 - 600 (UniProt: A0A0B4KEX2)
| PDB | External Database | Details |
|---|---|---|
| Ala 74 | Val 74 | engineered mutation |
| - | Ser 162 | deletion |
| - | Gln 163 | deletion |
| - | Asn 164 | deletion |
| - | Ala 165 | deletion |
| - | Ser 166 | deletion |
| - | Arg 167 | deletion |
| - | Val 168 | deletion |
| - | Pro 169 | deletion |
| - | Val 170 | deletion |
| - | Ile 171 | deletion |
| - | Gly 172 | deletion |
| - | Asn 173 | deletion |
| - | Tyr 174 | deletion |
| - | Ser 175 | deletion |
| - | Asp 176 | deletion |
| - | Leu 177 | deletion |
| - | Tyr 178 | deletion |
| - | Ala 179 | deletion |
| - | Met 180 | deletion |
| - | Gly 181 | deletion |
| - | Asn 182 | deletion |
| - | Gln 183 | deletion |
| - | Ser 184 | deletion |
| - | Leu 185 | deletion |
| - | Leu 186 | deletion |
| - | Tyr 187 | deletion |
| - | Asn 188 | deletion |
| - | Glu 189 | deletion |
| - | Thr 190 | deletion |
| - | Tyr 191 | deletion |
| - | Met 192 | deletion |
| - | Asn 193 | deletion |
| - | Gly 194 | deletion |
| - | Ser 195 | deletion |
| - | Ser 196 | deletion |
| - | Leu 197 | deletion |
| - | Asp 198 | deletion |
| - | Thr 199 | deletion |
| - | Ser 200 | deletion |
| - | Ala 201 | deletion |
| - | Val 202 | deletion |
| Ala 415 | Leu 415 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 106946.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1576.5 | |
| All* | Total formula weight | 109207.5 |
