4XNZ
Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (G, A, D) | Envelope glycoprotein gp160,Envelope glycoprotein gp160 | polymer | 353 | 39211.4 | 3 | UniProt (Q0ED31) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B, E, H (H, B, E) | HEAVY CHAIN OF ANTIBODY VRC06B | polymer | 234 | 25268.5 | 3 | Pfam (PF07654) UniProt (by SIFTS) (P01857) | Homo sapiens (Human) | |
| 3 | C, F, I (L, C, F) | LIGHT CHAIN OF ANTIBODY VRC06B | polymer | 209 | 23015.6 | 3 | Pfam (PF07654) UniProt (by SIFTS) (P01834) | Homo sapiens (Human) | |
| 4 | J, K, L (I, J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 5 | AA, BA, CA, DA, M... (D, G, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
G, A, D: 44 - 123 (UniProt: Q0ED31)
G, A, D: 199 - 301 (UniProt: Q0ED31)
G, A, D: 324 - 492 (UniProt: Q0ED31)
G, A, D: 199 - 301 (UniProt: Q0ED31)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | linker |
| Gly 198 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 318 | - | linker |
| Gly 319 | - | linker |
| Ser 320 | - | linker |
| Gly 321 | - | linker |
| Ser 322 | - | linker |
| Gly 323 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 262486.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1711.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 268180.1 |
