4XNZ

Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, A, D	Envelope glycoprotein gp160,Envelope glycoprotein gp160	polymer	353	39211.4	3	UniProt (Q0ED31) Pfam (PF00516) In PDB	Human immunodeficiency virus 1
2	H, B, E	HEAVY CHAIN OF ANTIBODY VRC06B	polymer	234	25268.5	3	Pfam (PF07654) UniProt (by SIFTS) (P01857) In PDB	Homo sapiens (Human)
3	L, C, F	LIGHT CHAIN OF ANTIBODY VRC06B	polymer	209	23015.6	3	Pfam (PF07654) UniProt (by SIFTS) (P01834) In PDB	Homo sapiens (Human)
4	I, J, K	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	3	In PDB GlyTouCan (G21290RB)
5	D, G, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)

Sequence modifications

G, A, D: 44 - 123 (UniProt: Q0ED31)
G, A, D: 199 - 301 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G, A, D: 324 - 492 (UniProt: Q0ED31)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	262486.7
Branched	Number of molecules	3
	Total formula weight	1711.6
Non-Polymers*	Number of molecules	18
	Total formula weight	3981.7
All*	Total formula weight	268180.1

*Water molecules are not included.