4XKI

Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor 1	polymer	147	16888.1	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (Human)	FGF-1,Acidic fibroblast growth factor,aFGF,Endothelial cell growth factor,ECGF,Heparin-binding growth factor 1,HBGF-1
2	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	E, F, G, I, J... (A, B)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
4	H (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	N (B)	NONAETHYLENE GLYCOL	non-polymer		414.5	1	Chemie (2PE)
6	O, P (A, B)	water	water		18.0	260	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
Met 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Arg 116	Ser 131	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33776.1
Non-Polymers*	Number of molecules	12
	Total formula weight	1458.5
All*	Total formula weight	35234.6

*Water molecules are not included.