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4XKI

Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
B0001525biological_processangiogenesis
B0001759biological_processorgan induction
B0005104molecular_functionfibroblast growth factor receptor binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0008083molecular_functiongrowth factor activity
B0008201molecular_functionheparin binding
B0008284biological_processpositive regulation of cell population proliferation
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009653biological_processanatomical structure morphogenesis
B0009887biological_processanimal organ morphogenesis
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0030154biological_processcell differentiation
B0030324biological_processlung development
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030544molecular_functionHsp70 protein binding
B0031012cellular_componentextracellular matrix
B0032148biological_processactivation of protein kinase B activity
B0034605biological_processcellular response to heat
B0042060biological_processwound healing
B0043406biological_processpositive regulation of MAP kinase activity
B0044548molecular_functionS100 protein binding
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0045766biological_processpositive regulation of angiogenesis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0051781biological_processpositive regulation of cell division
B0060681biological_processbranch elongation involved in ureteric bud branching
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0072163biological_processmesonephric epithelium development
B1901509biological_processregulation of endothelial tube morphogenesis
B1902533biological_processpositive regulation of intracellular signal transduction
B1903672biological_processpositive regulation of sprouting angiogenesis
B2000347biological_processpositive regulation of hepatocyte proliferation
B2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue SO4 A 201
ChainResidue
AASN18
ALYS112
ALYS113
ALYS118
AHOH346
AHOH393
BASP70

site_idAC2
Number of Residues8
Detailsbinding site for residue SO4 A 202
ChainResidue
ATYR125
AHOH326
BHIS1
BHIS1
BTYR125
BHOH335
AHIS1
AHIS1

site_idAC3
Number of Residues7
Detailsbinding site for residue PO4 A 203
ChainResidue
AASN106
AHIS124
ATYR125
AHOH329
AHOH336
AHOH379
BHIS1

site_idAC4
Number of Residues5
Detailsbinding site for residue PO4 A 204
ChainResidue
ALYS113
AGLN127
ALYS128
AHOH307
AHOH346

site_idAC5
Number of Residues4
Detailsbinding site for residue PO4 A 205
ChainResidue
ALYS112
AHOH303
AHOH368
BHOH315

site_idAC6
Number of Residues5
Detailsbinding site for residue GOL A 206
ChainResidue
AARG35
AARG37
BARG35
BARG37
BHOH321

site_idAC7
Number of Residues7
Detailsbinding site for residue PO4 B 201
ChainResidue
AHIS1
BASN106
BTHR123
BHIS124
BTYR125
BHOH318
BHOH372

site_idAC8
Number of Residues5
Detailsbinding site for residue PO4 B 202
ChainResidue
BLYS112
BLYS118
BARG122
BPO4203
BHOH306

site_idAC9
Number of Residues8
Detailsbinding site for residue PO4 B 203
ChainResidue
BASN18
BLYS112
BLYS113
BLYS118
BPO4202
BPO4205
BHOH308
BHOH346

site_idAD1
Number of Residues3
Detailsbinding site for residue PO4 B 204
ChainResidue
AARG122
AHIS124
BHOH339

site_idAD2
Number of Residues4
Detailsbinding site for residue PO4 B 205
ChainResidue
BLYS113
BLYS128
BPO4203
BHOH366

site_idAD3
Number of Residues13
Detailsbinding site for residue 2PE B 206
ChainResidue
ATYR15
AARG35
AARG37
ALEU135
APRO136
ASER138
BTYR15
BARG37
BLEU135
BPRO136
BSER138
BHOH317
BHOH321

Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY
ChainResidueDetails
AGLY71-TYR94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11069186, ECO:0000269|PubMed:9655399
ChainResidueDetails
AASN18
BASN18

224931

PDB entries from 2024-09-11

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